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Propofol-related infusion syndrome (PRIS) is a rare but severe condition associated with the administration of propofol, an anesthetic commonly used for sedation in medical procedures  First identified in the 1990s, PRIS can be fatal if not recognized and treated promptly Propofol-related infusion syndrome (PRIS) is a lethal condition characterized by multiple organ system failures  It can occur due to prolonged administration of propofol (an anesthetic) in mechanically intubated patients Propofol-related Infusion Syndrome (PRIS) is a life-threatening condition characterised by acute refractory bradycardia progressing to asystole and one or more of:pmc ncbi nlm nih gov articles PMC9794362Propofol-related infusion syndrome (PRIS) is a lethal condition characterized by multiple organ system failures  It can occur due to prolonged administration of propofol (an anesthetic) in mechanically intubated patients resusnation com propofol-infusion-syndromeMechanism of PRIS High doses of propofol (greater than 3mg kg h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic metabolism Propofol infusion syndrome (PRIS) is a multifactorial condition that, upon propofol administration, can interrupt critical cellular processes  This can lead to cellular damage that translates as multi-organ system failure that has the potential to be life-threatening Propofol is widely used to sedate agitated patients in intensive care units  However, it can cause a rare but fatal complication, propofol-related infusion syndrome (PRIS)  The pathophysiology of PRIS is not clear, and there is no definitive diagnosis and treatment en m wikipedia org wiki Propofol_infusion_syndromeMechanism of PRIS High doses of propofol (greater than 3mg kg h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic metabolism Feb 5, 2024 · Aside from propofol dose, other risk factors for PRIS include critical illness, use of vasopressors and steroids, starvation or malnutrition, and subclinical mitochondrial disease Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol Propofol infusion syndrome (PRIS) is a rare propofol complication, leading to cardiac failure  It was first described in critically ill children and in adults with traumatic brain injury pmc ncbi nlm nih gov articles PMC4470532Propofol infusion syndrome (PRIS) is a rare propofol complication, leading to cardiac failure  It was first described in critically ill children and in adults with traumatic brain injury Propofol-related Infusion Syndrome (PRIS) is a life-threatening condition characterised by acute refractory bradycardia progressing to asystole and one or more of:Apr 30, 2024 · Propofol-related infusion syndrome (PRIS) is a rare but severe condition associated with the administration of propofol, an anesthetic commonly used for sedation in medical procedures  First identified in the 1990s, PRIS can be fatal if not recognized and treated promptly pmc ncbi nlm nih gov articles PMC10030236Propofol infusion syndrome (PRIS) is a rare and potentially fatal condition that was first reported in children in 1990  It is characterized by profound metabolic acidosis and bradycardia which may ultimately lead to cardiac arrest litfl com propofol-related-infusion-syndromePropofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol pmc ncbi nlm nih gov articles PMC9671386first10em com propofol-related-infusion-syndrome-prisanesthesiologydfw com propofol-related-infusion-syndromeMay 13, 2021 · Propofol infusion syndrome (PRIS) is a rare and potentially fatal condition that was first reported in children in 1990  It is characterized by profound metabolic acidosis and bradycardia which may ultimately lead to cardiac arrest Propofol infusion syndrome (PRIS) is a multifactorial condition that, upon propofol administration, can interrupt critical cellular processes  This can lead to cellular damage that translates as multi-organ system failure that has the potential to be life-threatening cumming ucalgary ca     CPT%20Pearl%20Propofol%20Related%20Infusion%20Syndrom   Aside from propofol dose, other risk factors for PRIS include critical illness, use of vasopressors and steroids, starvation or malnutrition, and subclinical mitochondrial disease Propofol is widely used to sedate agitated patients in intensive care units  However, it can cause a rare but fatal complication, propofol-related infusion syndrome (PRIS)  The pathophysiology of PRIS is not clear, and there is no definitive diagnosis and treatment 

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