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As a result of drug resistance, antibiotics and other antimicrobial medicines become inefective and infections become increasingly diicult or impossible to treat Drug consumption can be expressed in cost, number of units, number of prescriptions or by the physical quantity of drugs However these variables can vary between regions and countries over time This limits comparisons of drug consumption at an international level To address this, a technical unit of measurement, the Defined Daily Dose (DDD) was created Drug consumption can be expressed in cost, number of units, number of prescriptions or by the physical quantity of drugs However these variables can vary between regions and countries over time This limits comparisons of drug consumption at an international level To address this, a technical unit of measurement, the Defined Daily Dose (DDD) was created Good Manufacturing Practices (GMP, also referred to as 'cGMP' or 'current Good Manufacturing Practice') is the aspect of quality assurance that ensures that medicinal products are consistently produced and controlled to the quality standards appropriate to their intended use and as required by the product specification Drug Utilization Research (DUR) uses the Anatomical Therapeutic Chemical (ATC) as the classification system and the Defined Daily Dose (DDD) as a unit of measure The ATC classification system groups the active medical substances according to the organ or system on which they act and according to their therapeutic, pharmacologic and chemical properties The DDD is a unit of measurement and is Note: For further guidance on validation of data-processing equipment, refer to documents published by the International Society for Pharmaceutical Engineering (13, 14), US Food and Drug Administration (15), European Commission (16) and the Offi cial Medicines Control Laboratories Network of the Council of Europe (17) About WHO Drug Information WHO Drug Information is a quarterly journal providing an overview of topics relating to medicines development and regulation which is targeted to a wide audience of health professionals and policy makers Launched in 1987, WHO Drug Information communicates the latest international news and trends to regulatory agencies, academic and training institutions, researchers --- who int tools atc-ddd-toolkit about-dddOur team provides authoritative guidance and standards on quality, safety and efficacy of health products and supports countries to formulate evidence-based policies and ensure good practice throughout the value chain For drug-drug interactions the WHO-UMC system can be used by assessing the actor drug, which influences the kinetics or dynamics of the other drug (which has usually been taken over a longer period), in the medical context of the patient --- who int docs default-source medicines trs992-annex4 pdf--- who int our-work who-drug-informationIn the Anatomical Therapeutic Chemical (ATC) classification system, the active substances are divided into different groups according to the organ or system on which they act and their therapeutic, pharmacological and chemical properties Drugs are classified in groups at five different levels For drug-drug interactions the WHO-UMC system can be used by assessing the actor drug, which influences the kinetics or dynamics of the other drug (which has usually been taken over a longer period), in the medical context of the patient --- who int trs957-annex1-goodpractices-harmaceuticalqualitycontrol-labor 1 Introduction and background Manufacturers should ensure that the products that they manufacture are safe, efective and of the quality required for their intended use Systems should be in place to ensure that pharmaceutical products are produced according to validated processes and to defined procedures Manufacturing processes should be shown to be capable of consistently manufacturing Good Manufacturing Practices (GMP, also referred to as 'cGMP' or 'current Good Manufacturing Practice') is the aspect of quality assurance that ensures that medicinal products are consistently produced and controlled to the quality standards appropriate to their intended use and as required by the product specification In the Anatomical Therapeutic Chemical (ATC) classification system, the active substances are divided into different groups according to the organ or system on which they act and their therapeutic, pharmacological and chemical properties Drugs are classified in groups at five different levels --- who int docs default-source antimicrobial-resistance amr-factsheet pdfAs a result of drug resistance, antibiotics and other antimicrobial medicines become inefective and infections become increasingly diicult or impossible to treat --- who int tools atc-ddd-toolkit atc-classification--- who int teams health-product-and-policy-standards inn--- who int teams health-product-policy-and-standards gmp--- who int docs default-source medicines whocausality-assessment pdfNote: For further guidance on validation of data-processing equipment, refer to documents published by the International Society for Pharmaceutical Engineering (13, 14), US Food and Drug Administration (15), European Commission (16) and the Offi cial Medicines Control Laboratories Network of the Council of Europe (17) 1 Introduction and background Manufacturers should ensure that the products that they manufacture are safe, efective and of the quality required for their intended use Systems should be in place to ensure that pharmaceutical products are produced according to validated processes and to defined procedures Manufacturing processes should be shown to be capable of consistently manufacturing Drug Utilization Research (DUR) uses the Anatomical Therapeutic Chemical (ATC) as the classification system and the Defined Daily Dose (DDD) as a unit of measure The ATC classification system groups the active medical substances according to the organ or system on which they act and according to 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