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Propofol infusion syndrome (PRIS) is a rare syndrome which affects patients undergoing long-term treatment with high doses of the anaesthetic and sedative drug propofol Propofol-related Infusion Syndrome (PRIS) is a life-threatening condition characterised by acute refractory bradycardia progressing to asystole and one or more of:Propofol-related infusion syndrome (PRIS) is a lethal condition characterized by multiple organ system failures  It can occur due to prolonged administration of propofol (an anesthetic) in mechanically intubated patients Apr 30, 2024 · Propofol-related infusion syndrome (PRIS) is a rare but severe condition associated with the administration of propofol, an anesthetic commonly used for sedation in medical procedures  First identified in the 1990s, PRIS can be fatal if not recognized and treated promptly Feb 5, 2024 · Aside from propofol dose, other risk factors for PRIS include critical illness, use of vasopressors and steroids, starvation or malnutrition, and subclinical mitochondrial disease If PRIS is suspected, propofol should be discontinued and an alterna-tive sedative agent initiated  General measures to support cardiac and renal function should be initiated promptly in patients with suspected PRIS Propofol infusion syndrome (PRIS) is a multifactorial condition that, upon propofol administration, can interrupt critical cellular processes  This can lead to cellular damage that translates as multi-organ system failure that has the potential to be life-threatening Mechanism of PRIS High doses of propofol (greater than 3mg kg h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic metabolism Propofol infusion syndrome (PRIS) is defined as an uncommon but potentially fatal condition that can occur in patients receiving prolonged propofol infusions, characterized by severe manifestations such as cardiac failure, rhabdomyolysis, metabolic acidosis, renal failure, and death May 13, 2021 · Propofol infusion syndrome (PRIS) is a rare and potentially fatal condition that was first reported in children in 1990  It is characterized by profound metabolic acidosis and bradycardia which may ultimately lead to cardiac arrest 

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